Recombinant Human Secreted frizzled-related protein 4 (SFRP4)

Uniprot Id

Q6FHJ7

Target Species

Human

Target Name

SFRP4

Target Full Name

Secreted frizzled-related protein 4

Target Function

Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP4 plays a role in bone morphogenesis. May also act as a regulator of adult uterine morphology and function. May also increase apoptosis during ovulation possibly through modulation of FZ1/FZ4/WNT4 signaling. Has phosphaturic effects by specifically inhibiting sodium-dependent phosphate uptake.

Target Involvement

Pyle disease (PYL)

Target Subcellular Location

Secreted. Note=Cytoplasmic in ovarian tumor cells.

Target Protein Families

Secreted frizzled-related protein (sFRP) family

Target Tissue Specificity

Expressed in mesenchymal cells. Highly expressed in the stroma of proliferative endometrium. Expressed in cardiomyocytes. Shows moderate to strong expression in ovarian tumors with expression increasing as the tumor stage increases. In ovarian tumors, exp

Target Synonyms

Frizzled protein; Frizzled protein human endometrium; FRP 4; FRP4; FrpHE; human endometrium; PYL; Secreted frizzled-related protein 4; sFRP-4; Sfrp4; SFRP4_HUMAN

Target Background

Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression.