Recombinant Human Selenocysteine insertion sequence-binding protein 2 (SECISBP2), Truncated

Uniprot Id

Q96T21

Target Species

Human

Target Name

SECISBP2

Target Full Name

Selenocysteine insertion sequence-binding protein 2

Target Function

Binds to the SECIS element in the 3'-UTR of some mRNAs encoding selenoproteins. Binding is stimulated by SELB.

Target Involvement

Abnormal thyroid hormone metabolism (ATHYHM)

Target Subcellular Location

[Isoform 1]: Nucleus.; [Isoform 2]: Mitochondrion.

Target Tissue Specificity

Expressed at high levels in testis.

Target Synonyms

DKFZp686C09169; OTTHUMP00000064929; OTTHUMP00000064930; OTTHUMP00000064931; OTTHUMP00000064932; RP11 89K14.1; SBP 2; SBP2; SEBP2_HUMAN; SECIS binding protein 2; SECIS-binding protein 2; SECISBP 2; SECISBP2; Selenocysteine insertion sequence binding protein 2; Selenocysteine insertion sequence-binding protein 2

Target Background

The protein encoded by this gene is one of the essential components of the machinery involved in co-translational insertion of selenocysteine (Sec) into selenoproteins. Sec is encoded by the UGA codon, which normally signals translation termination. The recoding of UGA as Sec codon requires a Sec insertion sequence (SECIS) element; present in the 3' untranslated regions of eukaryotic selenoprotein mRNAs. This protein specifically binds to the SECIS element, which is stimulated by a Sec-specific translation elongation factor. Mutations in this gene have been associated with reduction in enzymatic activity of type II iodothyronine deiodinase (a selenoprotein) and abnormal thyroid hormone metabolism. Alternatively spliced transcript variants have been found for this gene.