Recombinant Human Semaphorin-3C (SEMA3C)

Uniprot Id

Q99985

Target Species

Human

Target Name

SEMA3C

Target Full Name

Semaphorin-3C

Target Function

Binds to plexin family members and plays an important role in the regulation of developmental processes. Required for normal cardiovascular development during embryogenesis. Functions as attractant for growing axons, and thereby plays an important role in axon growth and axon guidance.

Target Subcellular Location

Secreted.

Target Protein Families

Semaphorin family

Target Tissue Specificity

Expressed intensely in the heart, skeletal muscle, colon, small intestine, ovary, testis, and prostate. Faint expression ubiquitously among other organs, including brain.

Target Synonyms

SEMA3C; SEMAE; Semaphorin-3C; Semaphorin-E; Sema E

Target Background

This gene encodes a secreted glycoprotein that belongs to the semaphorin class 3 family of neuronal guidance cues. The encoded protein contains an N-terminal sema domain, integrin and immunoglobulin-like domains, and a C-terminal basic domain. Homodimerization and proteolytic cleavage of the C-terminal propeptide are necessary for the function of the encoded protein. It binds a neuropilin co-receptor before forming a heterotrimeric complex with an associated plexin. An increase in the expression of this gene correlates with an increase in cancer cell invasion and adhesion. Naturally occurring mutations in this gene are associated with Hirschsprung disease.