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| Cat.No | ACP01886 | Target Name | SPINK1 |
|---|---|---|---|
| Target Synonyms | Pancreatic secretory trypsin inhibitor;Tumor-associated trypsin inhibitor;TATI | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 19-79aa |
| Mol Weight | 38.2 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P00995 |
|---|
Uniprot Id
P00995
Target Species
Human
Target Name
SPINK1
Target Full Name
Serine protease inhibitor Kazal-type 1
Target Function
Serine protease inhibitor which exhibits anti-trypsin activity. In the pancreas, protects against trypsin-catalyzed premature activation of zymogens.; In the male reproductive tract, binds to sperm heads where it modulates sperm capacitance by inhibiting calcium uptake and nitrogen oxide (NO) production.
Target Involvement
Pancreatitis, hereditary (PCTT); Tropical calcific pancreatitis (TCP)
Target Subcellular Location
Secreted.
Target Research Area
Cell Biology
Target Synonyms
ISK1_HUMAN; Pancreatic secretory trypsin inhibitor; Pancreatic serine protease inhibitor Kazal; PCTT; PSTI; Serine protease inhibitor Kazal type 1; Serine protease inhibitor Kazal-type 1; Spink 3; SPINK1; Spink3; TaTI; TCP; Tumor associated trypsin inhibitor; Tumor-associated trypsin inhibitor
Target Background
The protein encoded by this gene is a trypsin inhibitor, which is secreted from pancreatic acinar cells into pancreatic juice. It is thought to function in the prevention of trypsin-catalyzed premature activation of zymogens within the pancreas and the pancreatic duct. Mutations in this gene are associated with hereditary pancreatitis and tropical calcific pancreatitis.
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