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| Cat.No | ACP04421 | Target Name | AGXT |
|---|---|---|---|
| Target Synonyms | mitochondrial; Serine:pyruvate aminotransferase; SPAT; SPT; SPYA_HUMAN; TLH6 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-392aa |
| Mol Weight | 47.0kDa | Protein Length | Full length |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P21549 |
|---|
Uniprot Id
P21549
Target Species
Human
Target Name
AGXT
Target Full Name
Alanine--glyoxylate aminotransferase
Target Involvement
Hyperoxaluria primary 1 (HP1)
Target Subcellular Location
Peroxisome. Mitochondrion.
Target Protein Families
Class-V pyridoxal-phosphate-dependent aminotransferase family
Target Tissue Specificity
Liver.
Target Research Area
Signal Transduction, Metabolism
Target Synonyms
AGT; AGT1; Agxt; AGXT1; Alanine glyoxylate aminotransferase; Alanine glyoxylate aminotransferase3; Alanine--glyoxylate aminotransferase; EC 2.6.1.44; EC 2.6.1.51; Hepatic peroxisomal alanine glyoxylate aminotransferase; Hepatic peroxisomal alanine:glyoxylate aminotransferase; L alanine glyoxylate aminotransferase 1; MS773; PH1; Serine pyruvate aminotransferase; Serine--pyruvate aminotransferase; Serine--pyruvate aminotransferase, mitochondrial; Serine:pyruvate aminotransferase; SPAT; SPT; SPYA_HUMAN; TLH6
Target Background
This gene is expressed only in the liver and the encoded protein is localized mostly in the peroxisomes, where it is involved in glyoxylate detoxification. Mutations in this gene, some of which alter subcellular targetting, have been associated with type I primary hyperoxaluria.
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