Recombinant Human Serine/threonine-protein kinase 10 (STK10), Truncated

Uniprot Id

O94804

Target Species

Human

Target Name

STK10

Target Full Name

Serine/threonine-protein kinase 10

Target Function

Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.

Target Involvement

Testicular germ cell tumor (TGCT)

Target Subcellular Location

Cell membrane; Peripheral membrane protein.

Target Protein Families

Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily

Target Tissue Specificity

Highly expressed in rapidly proliferating tissues (spleen, placenta, and peripheral blood leukocytes). Also expressed in brain, heart, skeletal muscle, colon, thymus, kidney, liver, small intestine and lung.

Target Synonyms

LOK; Lymphocyte oriented kinase; Lymphocyte-oriented kinase; PRO2729; Serine threonine protein kinase 10; Serine/threonine-protein kinase 10; STK10; STK10_HUMAN

Target Background

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.