Recombinant Human Serine/threonine-protein kinase 38 (STK38)

Uniprot Id

Q15208

Target Species

Human

Target Name

STK38

Target Full Name

Serine/threonine-protein kinase 38

Target Function

Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2.

Target Subcellular Location

Nucleus. Cytoplasm.

Target Protein Families

Protein kinase superfamily, AGC Ser/Thr protein kinase family

Target Tissue Specificity

Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.

Target Synonyms

NDR 1; NDR; Ndr Ser/Thr kinase-like protein; NDR1; NDR1 protein kinase; Nuclear Dbf2 related kinase 1; nuclear Dbf2-related 1; Nuclear Dbf2-related kinase 1; Nuclear Dbf2-related protein; Serine/threonine protein kinase 38; Serine/threonine-protein kinase 38; STK 38; STK38; STK38_HUMAN

Target Background

This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants.