Recombinant Human Serine/threonine-protein kinase D3 (PRKD3), Truncated

Uniprot Id

O94806

Target Species

Human

Target Name

PRKD3

Target Full Name

Serine/threonine-protein kinase D3

Target Function

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. Involved in resistance to oxidative stress.

Target Subcellular Location

Cytoplasm. Membrane. Note=Translocation to the cell membrane is required for kinase activation.

Target Protein Families

Protein kinase superfamily, CAMK Ser/Thr protein kinase family, PKD subfamily

Target Tissue Specificity

Ubiquitous.

Target Synonyms

EPK 2; EPK2; KPCD3_HUMAN; nPKC nu; nPKC-nu; nPKCnu; nu; PKCnu; PKD 3; PKD3; PRK D3; PRKCN; PRKD 3; Prkd3; Protein kinase C; Protein kinase C nu; Protein kinase C nu type; Protein kinase D3; Protein kinase EPK 2; Protein kinase EPK2; Serine threonine protein kinase; Serine/threonine protein kinase D3; Serine/threonine-protein kinase D3

Target Background

This gene belongs to the multigene protein kinase D family of serine/threonine kinases, which bind diacylglycerol and phorbol esters. Members of this family are characterized by an N-terminal regulatory domain comprised of a tandem repeat of cysteine-rich zinc-finger motifs and a pleckstrin domain. The C-terminal region contains the catalytic domain and is distantly related to calcium-regulated kinases. Catalytic activity of this enzyme promotes its nuclear localization. This protein has been implicated in a variety of functions including negative regulation of human airway epithelial barrier formation, growth regulation of breast and prostate cancer cells, and vesicle trafficking.