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| Cat.No | ACP16396 | Target Name | ERN2 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Protein Length | Partial | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q76MJ5 |
|---|
Uniprot Id
Q76MJ5
Target Species
Human
Target Name
ERN2
Target Full Name
Serine/threonine-protein kinase/endoribonuclease IRE2
Target Function
Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
Target Subcellular Location
Endoplasmic reticulum membrane; Single-pass type I membrane protein.
Target Protein Families
Protein kinase superfamily, Ser/Thr protein kinase family
Target Synonyms
ERN2; IRE2Serine/threonine-protein kinase/endoribonuclease IRE2; Endoplasmic reticulum-to-nucleus signaling 2; Inositol-requiring protein 2; hIRE2p; Ire1-beta; IRE1b) [Includes: Serine/threonine-protein kinase; EC 2.7.11.1); Endoribonuclease; EC 3.1.26.-)]
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