Recombinant Human Serine/threonine-protein kinase Nek8 (NEK8), Truncated

Uniprot Id

Q86SG6

Target Species

Human

Target Name

NEK8

Target Full Name

Serine/threonine-protein kinase Nek8

Target Function

Required for renal tubular integrity. May regulate local cytoskeletal structure in kidney tubule epithelial cells. May regulate ciliary biogenesis through targeting of proteins to the cilia. Plays a role in organogenesis and is involved in the regulation of the Hippo signaling pathway.

Target Involvement

Nephronophthisis 9 (NPHP9); Renal-hepatic-pancreatic dysplasia 2 (RHPD2)

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, cilium. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

Target Protein Families

Protein kinase superfamily, NEK Ser/Thr protein kinase family, NIMA subfamily

Target Tissue Specificity

Highest expression in thyroid, adrenal gland and skin. Low levels in spleen, colon and uterus. Overexpressed in breast tumors, with highest expression in infiltrating ductal carcinomas and moderate levels in mucinous adenocarcinoma.

Target Synonyms

JCK; NEK 8; NEK12A; NEK8; NEK8_HUMAN; Nephrocystin 9; Never in mitosis A-related kinase 8; NIMA (never in mitosis gene a) related kinase 8; NIMA related kinase 8; NIMA-family kinase NEK8; NIMA-related kinase 12a ; Nima-related protein kinase 12a; NimA-related protein kinase 8; NPHP9; Serine/threonine-protein kinase Nek8

Target Background

This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans.