Recombinant Human Serine/threonine-protein phosphatase 6 catalytic subunit (PPP6C)

Uniprot Id

O00743

Target Species

Human

Target Name

PPP6C

Target Full Name

Serine/threonine-protein phosphatase 6 catalytic subunit

Target Function

Catalytic subunit of protein phosphatase 6 (PP6). PP6 is a component of a signaling pathway regulating cell cycle progression in response to IL2 receptor stimulation. N-terminal domain restricts G1 to S phase progression in cancer cells, in part through control of cyclin D1. During mitosis, regulates spindle positioning. Downregulates MAP3K7 kinase activation of the IL1 signaling pathway by dephosphorylation of MAP3K7. Participates also in the innate immune defense against viruses by desphosphorylating RIG-I/DDX58, an essential step that triggers RIG-I/DDX58-mediated signaling activation.

Target Subcellular Location

Mitochondrion. Cytoplasm.

Target Protein Families

PPP phosphatase family, PP-6 (PP-V) subfamily

Target Tissue Specificity

Ubiquitously expressed in all tissues tested with highest expression levels in testis, heart, kidney, brain, stomach, liver and skeletal muscle and lowest in placenta, lung colon and spleen.

Target Synonyms

FLJ92648; MGC12249; PP 6; PP6; PP6C; PPP 6; PPP 6C; PPP6; PPP6_HUMAN; Ppp6c; Protein phosphatase 6 catalytic subunit; Serine/threonine protein phosphatase 6; Serine/threonine protein phosphatase catalytic subunit ; Serine/threonine-protein phosphatase 6 catalytic subunit

Target Background

This gene encodes the catalytic subunit of protein phosphatase, a component of a signaling pathway regulating cell cycle progression. Splice variants encoding different protein isoforms exist. The pseudogene of this gene is located on chromosome X.