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The region for expressing recombinant Human SERPINB4 contains amino acids 1-390. The theoretical molecular weight of the SERPINB4 protein is 60.9 kDa. The SERPINB4 protein was expressed in e.coli. The SERPINB4 coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant SERPINB4 protein in following stages of expression and purification.Serpin B4 (SERPINB4), a member of the serine protease inhibitor (serpin) superfamily, plays a role in regulating proteolytic processes. SERPINB4 is primarily expressed in squamous epithelial tissues and has been implicated in various physiological and pathological conditions. SERPINB4 is known to inhibit specific serine proteases, thereby modulating processes like inflammation, tissue remodeling, and immune response. Research on SERPINB4 includes investigations into its involvement in cancer, particularly in squamous cell carcinomas, where its dysregulation may contribute to tumor progression and metastasis. Understanding the functions and regulatory mechanisms of SERPINB4 can provide insights into its potential as a therapeutic target in diseases associated with aberrant protease activity.
The region for expressing recombinant Human SERPINB4 contains amino acids 1-390. The theoretical molecular weight of the SERPINB4 protein is 60.9 kDa. The SERPINB4 protein was expressed in e.coli. The SERPINB4 coding gene included the N-terminal 6xHis-SUMO tag, which simplifies the detection and purification processes of the recombinant SERPINB4 protein in following stages of expression and purification.Serpin B4 (SERPINB4), a member of the serine protease inhibitor (serpin) superfamily, plays a role in regulating proteolytic processes. SERPINB4 is primarily expressed in squamous epithelial tissues and has been implicated in various physiological and pathological conditions. SERPINB4 is known to inhibit specific serine proteases, thereby modulating processes like inflammation, tissue remodeling, and immune response. Research on SERPINB4 includes investigations into its involvement in cancer, particularly in squamous cell carcinomas, where its dysregulation may contribute to tumor progression and metastasis. Understanding the functions and regulatory mechanisms of SERPINB4 can provide insights into its potential as a therapeutic target in diseases associated with aberrant protease activity.
| Cat.No | ACP03720 | Target Name | SERPINB4 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-390aa | Mol Weight | 60.9kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P48594 |
|---|
Uniprot Id
P48594
Target Species
Human
Target Name
SERPINB4
Target Full Name
Serpin B4
Target Function
May act as a protease inhibitor to modulate the host immune response against tumor cells.
Target Subcellular Location
Cytoplasm. Note=Seems to also be secreted in plasma by cancerous cells but at a low level.
Target Protein Families
Serpin family, Ov-serpin subfamily
Target Tissue Specificity
Squamous cells.
Target Research Area
Cancer
Target Synonyms
Leupin; Peptidase inhibitor 11; PI 11; PI-11; PI11; Protease inhibitor (leucine serpin); SCCA 2; SCCA-2; SCCA1; SCCA2; SCCA2/SCCA1 fusion protein; Serine (or cysteine) proteinase inhibitor; clade B (ovalbumin); member 4; Serpin B4; Serpin peptidase inhibitor; clade B (ovalbumin); member 4; SERPINB 4; SERPINB4; SPB4_HUMAN; Squamous cell carcinoma antigen 1; Squamous cell carcinoma antigen 2
Target Background
The protein encoded by this gene is a member of the serpin family of serine protease inhibitors. The encoded protein is highly expressed in many tumor cells and can inactivate granzyme M, an enzyme that kills tumor cells. This protein, along with serpin B3, can be processed into smaller fragments that aggregate to form an autoantigen in psoriasis, probably by causing chronic inflammation.
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