Recombinant Human Sestrin-2 (SESN2)

Uniprot Id

P58004

Target Species

Human

Target Name

SESN2

Target Full Name

Sestrin-2

Target Function

Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway through the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling. Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway. This stress-inducible metabolic regulator also plays a role in protection against oxidative and genotoxic stresses. May negatively regulate protein translation in response to endoplasmic reticulum stress, via TORC1. May positively regulate the transcription by NFE2L2 of genes involved in the response to oxidative stress by facilitating the SQSTM1-mediated autophagic degradation of KEAP1. May also mediate TP53 inhibition of TORC1 signaling upon genotoxic stress. Moreover, may prevent the accumulation of reactive oxygen species (ROS) through the alkylhydroperoxide reductase activity born by the N-terminal domain of the protein. Was originally reported to contribute to oxidative stress resistance by reducing PRDX1. However, this could not be confirmed.

Target Subcellular Location

Cytoplasm.

Target Protein Families

Sestrin family

Target Tissue Specificity

Widely expressed.

Target Synonyms

DKFZp761M0212; DKFZp761M02121; Hi95; Hypoxia induced gene 95; MGC11758; OTTHUMP00000003641; OTTMUSP00000010184; RP23 63D8.3; SES2; SESN 2; SESN2; SESN2_HUMAN; SEST2; Sestrin 2; Sestrin-2

Target Background

This gene encodes a member of the sestrin family of PA26-related proteins. The encoded protein may function in the regulation of cell growth and survival. This protein may be involved in cellular response to different stress conditions.