Recombinant Human Short transient receptor potential channel 4 (TRPC4), Truncated

Cat.No	ACP05713	Target Name	TRPC4
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05713

Target Name

TRPC4

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9UBN4

Background Information

Uniprot Id

Q9UBN4
Target Species

Human
Target Name

TRPC4
Target Full Name

Short transient receptor potential channel 4
Target Function

Forms a receptor-activated non-selective calcium permeant cation channel. Acts as a cell-cell contact-dependent endothelial calcium entry channel. Probably operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Mediates cation entry, with an enhanced permeability to barium over calcium. May also be activated by intracellular calcium store depletion.
Target Subcellular Location

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Note=Enhanced insertion into the cell membrane after activation of the EGF receptor.
Target Protein Families

Transient receptor (TC 1.A.4) family, STrpC subfamily, TRPC4 sub-subfamily
Target Tissue Specificity

Strongly expressed in placenta. Expressed at lower levels in heart, pancreas, kidney and brain. Expressed in endothelial cells. Isoform alpha was found to be the predominant isoform. Isoform beta was not found in pancreas and brain.
Target Synonyms

CCE1; HTRP 4; hTrp-4; hTrp4; MGC119570; MGC119571; MGC119572; MGC119573; RP11-10M8.1; Short transient receptor potential channel 4; STRPC4; Transient receptor potential 4; transient receptor potential cation channel subfamily C; Transient receptor potential cation channel subfamily C member 4; transient receptor potential channel 4; TRP 4; trp related protein 4; Trp-related protein 4; TRP4; TRPC 4; TrpC4; TRPC4 protein; TRPC4_HUMAN
Target Background

This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Recombinant Human Short transient receptor potential channel 4 (TRPC4), Truncated

Specifications

Immunogen Information

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