Recombinant Human Short-wave-sensitive opsin 1 (OPN1SW), Truncated

Uniprot Id

P03999

Target Species

Human

Target Name

OPN1SW

Target Full Name

Short-wave-sensitive opsin 1

Target Function

Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. Required for the maintenance of cone outer segment organization in the ventral retina, but not essential for the maintenance of functioning cone photoreceptors. Involved in ensuring correct abundance and localization of retinal membrane proteins. May increase spectral sensitivity in dim light.

Target Involvement

Tritan color blindness (CBT)

Target Subcellular Location

Cell membrane; Multi-pass membrane protein. Photoreceptor inner segment. Cell projection, cilium, photoreceptor outer segment. Cytoplasm, perinuclear region.

Target Protein Families

G-protein coupled receptor 1 family, Opsin subfamily

Target Tissue Specificity

The three color pigments are found in the cone photoreceptor cells. Expressed throughout the epidermis and dermis, primarily in the stratum granulosum in the facial and abdominal skin (at protein level). Expressed in dermal fibroblasts (at protein level).

Target Synonyms

OPN1SW; BCP; Short-wave-sensitive opsin 1; Blue cone photoreceptor pigment; Blue-sensitive opsin; BOP