Recombinant Human Sialic acid-binding Ig-like lectin 12 (SIGLEC12), Truncated

Cat.No	ACP14346	Target Name	SIGLEC12
Target Synonyms	SIGLEC12; SIGLECL1; SLG; UNQ9215/PRO34042Sialic acid-binding Ig-like lectin 12; Siglec-12; Sialic acid-binding Ig-like lectin-like 1; Siglec-L1	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP14346

Target Name

SIGLEC12

Target Synonyms

SIGLEC12; SIGLECL1; SLG; UNQ9215/PRO34042Sialic acid-binding Ig-like lectin 12; Siglec-12; Sialic acid-binding Ig-like lectin-like 1; Siglec-L1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q96PQ1

Background Information

Uniprot Id

Q96PQ1
Target Species

Human
Target Name

SIGLEC12
Target Full Name

Sialic acid-binding Ig-like lectin 12
Target Function

Putative adhesion molecule that mediates sialic-acid dependent binding to cells. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.
Target Subcellular Location

Membrane; Single-pass type I membrane protein.
Target Protein Families

Immunoglobulin superfamily, SIGLEC (sialic acid binding Ig-like lectin) family
Target Tissue Specificity

Isoform Short is highly expressed in spleen, small intestine and adrenal gland; it is lower expressed in thyroid, placenta, brain, stomach, bone marrow, spinal chord and breast. Isoform Long is highly expressed in spleen, small intestine and bone marrow;
Target Synonyms

SIGLEC12; SIGLECL1; SLG; UNQ9215/PRO34042Sialic acid-binding Ig-like lectin 12; Siglec-12; Sialic acid-binding Ig-like lectin-like 1; Siglec-L1
Target Background

Sialic acid-binding immunoglobulin-like lectins (SIGLECs) are a family of cell surface proteins belonging to the immunoglobulin superfamily. They mediate protein-carbohydrate interactions by selectively binding to different sialic acid moieties present on glycolipids and glycoproteins. This gene encodes a member of the SIGLEC3-like subfamily of SIGLECs. Members of this subfamily are characterized by an extracellular V-set immunoglobulin-like domain followed by two C2-set immunoglobulin-like domains, and the cytoplasmic tyrosine-based motifs ITIM and SLAM-like. The encoded protein, upon tyrosine phosphorylation, has been shown to recruit the Src homology 2 domain-containing protein-tyrosine phosphatases SHP1 and SHP2. It has been suggested that the protein is involved in the negative regulation of macrophage signaling by functioning as an inhibitory receptor. This gene is located in a cluster with other SIGLEC3-like genes on 19q13.4. Alternative splicing results in multiple transcript variants.

Recombinant Human Sialic acid-binding Ig-like lectin 12 (SIGLEC12), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human Sialic acid-binding Ig-like lectin 12 (SIGLEC12), Truncated Now

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