Recombinant Human Sialidase-2 (NEU2)

Uniprot Id

Q9Y3R4

Target Species

Human

Target Name

NEU2

Target Full Name

Sialidase-2

Target Function

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Recognizes sialyl linkage positions of the glycan moiety as well as the supramolecular organization of the sialoglycoconjugate. Displays preference for alpha-(2->3)-sialylated GD1a and GT1B gangliosides over alpha-(2->8)-sialylated GD1b, in both monomeric forms and micelles. Hydrolyzes monomeric GM1 ganglioside, but has no activity toward the miscellar form. Has lower sialidase activity for glycoproteins such as fetuin and TF/transferrin that carry a mixture of alpha-(2->3) and alpha-(2->6)-sialyl linkages. Cleaves milk oligosaccharide alpha-(2->3)-sialyllactose, but is inactive toward alpha-(2->6)-sialyllactose isomer. Has no activity toward colominic acid, a homomer of alpha-(2->8)-linked Neu5Ac residues.

Target Subcellular Location

Cytoplasm, cytosol.

Target Protein Families

Glycosyl hydrolase 33 family

Target Tissue Specificity

Expressed in skeletal muscle, fetal liver and embryonic carcinoma cell line NT2-D1.

Target Research Area

Signal Transduction

Target Synonyms

Cytosolic sialidase; MGC129579; N acetyl alpha neuraminidase 2; N-acetyl-alpha-neuraminidase 2; Neu2; NEUR2_HUMAN; Neuraminidase 2; OTTHUMP00000164374; SIAL2; Sialidase 2; Sialidase-2

Target Background

This gene belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. Expression studies in COS7 cells confirmed that this gene encodes a functional sialidase. Its cytosolic localization was demonstrated by cell fractionation experiments.