Recombinant Human Sialidase-4 (NEU4)

Cat.No	ACP13290	Target Name	NEU4
Target Synonyms	NEU4; LP5125Sialidase-4; EC 3.2.1.18; N-acetyl-alpha-neuraminidase 4	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-484
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP13290

Target Name

NEU4

Target Synonyms

NEU4; LP5125Sialidase-4; EC 3.2.1.18; N-acetyl-alpha-neuraminidase 4

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-484

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q8WWR8

Background Information

Uniprot Id

Q8WWR8
Target Species

Human
Target Name

NEU4
Target Full Name

Sialidase-4
Target Function

Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3. Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons. May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation. Has sialidase activity toward mucin, fetuin and sialyllactose.
Target Subcellular Location

[Isoform 1]: Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein. Mitochondrion membrane; Peripheral membrane protein. Cell projection, neuron projection.; [Isoform 2]: Mitochondrion inner membrane; Peripheral membrane protein. Mitochondrion outer membrane; Peripheral membrane protein. Lysosome lumen. Note=According to PubMed:15213228, isoform 2 is soluble, N-glycosylated and found in the lumen of lysosomes. However, no signal sequence nor N-glycosylation site is predicted from the sequence.
Target Protein Families

Glycosyl hydrolase 33 family
Target Tissue Specificity

[Isoform 1]: Predominant form in liver. Also expressed in brain, kidney and colon.; [Isoform 2]: Highly expressed in brain and at lower levels in kidney and liver.
Target Synonyms

NEU4; LP5125Sialidase-4; EC 3.2.1.18; N-acetyl-alpha-neuraminidase 4

Recombinant Human Sialidase-4 (NEU4)

Specifications

Immunogen Information

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