Recombinant Human Signal transducer and activator of transcription 4 (STAT4)

Uniprot Id

Q14765

Target Species

Human

Target Name

STAT4

Target Full Name

Signal transducer and activator of transcription 4

Target Function

Carries out a dual signal transduction and activation of transcription. Involved in IL12 signaling.

Target Involvement

Systemic lupus erythematosus 11 (SLEB11); Rheumatoid arthritis (RA)

Target Subcellular Location

Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.

Target Protein Families

Transcription factor STAT family

Target Synonyms

Signal transducer and activator of transcription 4; SLEB11; STAT4; STAT4_HUMAN

Target Background

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.