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Recombinant Human Single-stranded DNA cytosine deaminase (AICDA)

ACP19001

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Specifications

Cat.No	ACP19001	Target Name	AICDA
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Expression Range	1-198	Protein Length	Full length protein
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9GZX7

Background Information

Uniprot Id

Q9GZX7
Target Species

Human
Target Name

AICDA
Target Full Name

Single-stranded DNA cytosine deaminase
Target Function

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.
Target Involvement

Immunodeficiency with hyper-IgM 2 (HIGM2)
Target Subcellular Location

Nucleus. Cytoplasm.
Target Protein Families

Cytidine and deoxycytidylate deaminase family
Target Tissue Specificity

Strongly expressed in lymph nodes and tonsils.
Target Research Area

Epigenetics and Nuclear Signaling
Target Synonyms

Activation induced cytidine deaminase; Activation induced deaminase; Activation-induced cytidine deaminase; AICDA; AICDA_HUMAN; AID; ARP 2; ARP2; CDA 2; CDA2; Cytidine aminohydrolase; HIGM2; Integrated into Burkitt's lymphoma cell line Ramos

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Recombinant Human Single-stranded DNA cytosine deaminase (AICDA)

Specifications

Immunogen Information

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