Recombinant Human Smad nuclear-interacting protein 1 (SNIP1)

Uniprot Id

Q8TAD8

Target Species

Human

Target Name

SNIP1

Target Full Name

Smad nuclear-interacting protein 1

Target Function

Required for pre-mRNA splicing as component of the spliceosome. Down-regulates NF-kappa-B signaling by competing with RELA for CREBBP/EP300 binding. Involved in the microRNA (miRNA) biogenesis. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA.

Target Involvement

Psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED)

Target Subcellular Location

Nucleus.

Target Tissue Specificity

Ubiquitous, with highest expression in heart and skeletal muscle.

Target Synonyms

FHA domain containing protein SNIP1; FHA domain-containing protein SNIP1; FLJ12553; PMRED; Smad nuclear interacting protein (Smad nuclear interacting); smad nuclear interacting protein 1; Smad nuclear interacting protein; Smad nuclear-interacting protein 1; SNIP1 (Smad nuclear interacting protein); SNIP1; SNIP1_HUMAN; Splicing factor arginine/serine rich 4 (Pre mRNA splicing factor SRP75)

Target Background

This gene encodes a protein that contains a coiled-coil motif and C-terminal forkhead-associated (FHA) domain. The encoded protein functions as a transcriptional coactivator that increases c-Myc activity and inhibits transforming growth factor beta (TGF-beta) and nuclear factor kappa-B (NF-kB) signaling. The encoded protein also regulates the stability of cyclin D1 mRNA, and may play a role in cell proliferation and cancer progression. Mutations in this gene are a cause of psychomotor retardation, epilepsy, and craniofacial dysmorphism (PMRED).