Recombinant Human Small nuclear ribonucleoprotein E (SNRPE)

Uniprot Id

P62304

Target Species

Human

Target Name

SNRPE

Target Full Name

Small nuclear ribonucleoprotein E

Target Function

Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.

Target Involvement

Hypotrichosis 11 (HYPT11)

Target Subcellular Location

Cytoplasm, cytosol. Nucleus.

Target Protein Families

SnRNP Sm proteins family

Target Tissue Specificity

Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis.

Target Synonyms

AL022645; B raf; B-raf; Braf; C76690; HYPT11; RUXE_HUMAN; Sm protein E; Sm-E; Small nuclear ribonucleoprotein E; SmE; snRNP-E; snRNPE; snrpe

Target Background

The protein encoded by this gene is a core component of U small nuclear ribonucleoproteins, which are key components of the pre-mRNA processing spliceosome. The encoded protein plays a role in the 3' end processing of histone transcripts. This protein is one of the targets in the autoimmune disease systemic lupus erythematosus, and mutations in this gene have been associated with hypotrichosis. Several pseudogenes of this gene have been identified.