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| Cat.No | ACP14947 | Target Name | SCN4B |
|---|---|---|---|
| Target Synonyms | SCN4B; Sodium channel subunit beta-4 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q8IWT1 |
|---|
Uniprot Id
Q8IWT1
Target Species
Human
Target Name
SCN4B
Target Full Name
Sodium channel regulatory subunit beta-4
Target Function
Modulates channel gating kinetics. Causes negative shifts in the voltage dependence of activation of certain alpha sodium channels, but does not affect the voltage dependence of inactivation. Modulates the susceptibility of the sodium channel to inhibition by toxic peptides from spider, scorpion, wasp and sea anemone venom.
Target Involvement
Long QT syndrome 10 (LQT10); Atrial fibrillation, familial, 17 (ATFB17)
Target Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Target Protein Families
Sodium channel auxiliary subunit SCN4B (TC 8.A.17) family
Target Tissue Specificity
Expressed at a high level in dorsal root ganglia, at a lower level in brain, spinal cord, skeletal muscle and heart. Expressed in the atrium.
Target Synonyms
SCN4B; Sodium channel subunit beta-4
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