Recombinant Human Sodium/glucose cotransporter 2 (SLC5A2)-VLPs

Uniprot Id

P31639

Target Species

Human

Target Name

SLC5A2

Target Full Name

Sodium/glucose cotransporter 2

Target Function

Sodium-dependent glucose transporter. Has a Na(+) to glucose coupling ratio of 1:1.; Efficient substrate transport in mammalian kidney is provided by the concerted action of a low affinity high capacity and a high affinity low capacity Na(+)/glucose cotransporter arranged in series along kidney proximal tubules.

Target Involvement

Renal glucosuria (GLYS)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Sodium:solute symporter (SSF) (TC 2.A.21) family

Target Research Area

Signal Transduction

Target Synonyms

SLC5A2; SGLT2; Sodium/glucose cotransporter 2; Na(+/glucose cotransporter 2; Low affinity sodium-glucose cotransporter; Solute carrier family 5 member 2

Target Background

This gene encodes a member of the sodium glucose cotransporter family which are sodium-dependent glucose transport proteins. The encoded protein is the major cotransporter involved in glucose reabsorption in the kidney. Mutations in this gene are associated with renal glucosuria. Two transcript variants, one protein-coding and one not, have been found for this gene.