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Recombinant Human Sodium/hydrogen exchanger 6 (SLC9A6), Truncated

ACP05955

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP05955 Target NameSLC9A6
FormLyophilized powderExpression SystemCustom Production. Please inquire and provide the desire expression system.
Protein LengthPartialPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ92581
Background Information
  • Uniprot Id

    Q92581

  • Target Species

    Human

  • Target Name

    SLC9A6

  • Target Full Name

    Sodium/hydrogen exchanger 6

  • Target Function

    Electroneutral exchange of protons for Na(+) and K(+) across the early and recycling endosome membranes. Contributes to calcium homeostasis.

  • Target Involvement

    Mental retardation, X-linked, syndromic, Christianson type (MRXSCH)

  • Target Subcellular Location

    Endosome membrane; Multi-pass membrane protein. Note=Is present in the recycling compartments including early and recycling endosomes, and only appears transiently on the plasma membrane.; [Isoform 2]: Recycling endosome membrane; Multi-pass membrane protein.

  • Target Protein Families

    Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family

  • Target Tissue Specificity

    Ubiquitous; but is most abundant in mitochondrion-rich tissues such as brain, skeletal muscle and heart.

  • Target Synonyms

    3732426M05; 6430520C02Rik; KIAA0267; mKIAA0267; MRSA; Na(+)/H(+) exchanger 6; NHE-6; NHE6; OTTHUMP00000024089; OTTHUMP00000024090; RGD1563582; RP11-274K13.1; RP23-105E2.4; SL9A6_HUMAN; SLC9A6; Sodium/hydrogen exchanger 6; Solute carrier family 9 (sodium/hydrogen exchanger); isoform 6; Solute carrier family 9 (sodium/hydrogen exchanger); member 6; Solute carrier family 9 member 6; solute carrier family 9; subfamily A (NHE6; cation proton antiporter 6); member 6

  • Target Background

    This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic cognitive disability, Christianson type. Alternate splicing results in multiple transcript variants.

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