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The expression region of this recombinant Human SLC5A5 covers amino acids 547-643. The calculated molecular weight for this SLC5A5 protein is 17.4 kDa. This SLC5A5 protein is produced using e.coli expression system. The SLC5A5 coding gene included the C-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant SLC5A5 protein in following stages of expression and purification.The human sodium/iodide cotransporter (SLC5A5) is a crucial membrane protein involved in the active transport of iodide ions across the cell membrane. Mainly expressed in thyroid follicular cells, SLC5A5 plays a pivotal role in thyroid hormone synthesis. It facilitates the uptake of iodide from the bloodstream into thyroid cells, an essential step for the production of thyroid hormones, thyroxine (T4), and triiodothyronine (T3). This process is integral to the regulation of metabolism and overall physiological homeostasis. Additionally, due to its ability to concentrate iodide, SLC5A5 has been utilized in medical imaging and radioiodine therapy for thyroid disorders, including thyroid cancer.
The expression region of this recombinant Human SLC5A5 covers amino acids 547-643. The calculated molecular weight for this SLC5A5 protein is 17.4 kDa. This SLC5A5 protein is produced using e.coli expression system. The SLC5A5 coding gene included the C-terminal 6xHis tag, which simplifies the detection and purification processes of the recombinant SLC5A5 protein in following stages of expression and purification.The human sodium/iodide cotransporter (SLC5A5) is a crucial membrane protein involved in the active transport of iodide ions across the cell membrane. Mainly expressed in thyroid follicular cells, SLC5A5 plays a pivotal role in thyroid hormone synthesis. It facilitates the uptake of iodide from the bloodstream into thyroid cells, an essential step for the production of thyroid hormones, thyroxine (T4), and triiodothyronine (T3). This process is integral to the regulation of metabolism and overall physiological homeostasis. Additionally, due to its ability to concentrate iodide, SLC5A5 has been utilized in medical imaging and radioiodine therapy for thyroid disorders, including thyroid cancer.
| Cat.No | ACP01174 | Target Name | SLC5A5 |
|---|---|---|---|
| Target Synonyms | (Na(+)(-)(Natrium iodide transporter)(Sodium-iodide symporter)(Na(+)(-)(Solute carrier family 5 member 5) | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 547-643aa |
| Mol Weight | 17.4 kDa | Protein Length | Partial |
| Purity | Greater than 90% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q92911 |
|---|
Uniprot Id
Q92911
Target Species
Human
Target Name
SLC5A5
Target Full Name
Sodium/iodide cotransporter
Target Function
Mediates iodide uptake in the thyroid gland.
Target Involvement
Thyroid dyshormonogenesis 1 (TDH1)
Target Subcellular Location
Membrane; Multi-pass membrane protein.
Target Protein Families
Sodium:solute symporter (SSF) (TC 2.A.21) family
Target Tissue Specificity
Expression is primarily in thyroid tissue, but also to a lower extent in mammary gland and ovary. Expression is reduced in tumors.
Target Research Area
Others
Target Synonyms
Na(+)/I(-) cotransporter; Na(+)/I(-) symporter; Na+/I- cotransporter; Na+/I-symporter; NIS; SC5A5_HUMAN; Slc5a5; sodium iodide symporter; Sodium-iodide symporter; Sodium/iodide cotransporter; Solute carrier family 5 (sodium iodide symporter) member 5; solute carrier family 5 (sodium/iodide cotransporter), member 5; Solute carrier family 5 member 5; TDH1
Target Background
This gene encodes a member of the sodium glucose cotransporter family. The encoded protein is responsible for the uptake of iodine in tissues such as the thyroid and lactating breast tissue. The iodine taken up by the thyroid is incorporated into the metabolic regulators triiodothyronine (T3) and tetraiodothyronine (T4). Mutations in this gene are associated with thyroid dyshormonogenesis 1.
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