Recombinant Human Sodium leak channel non-selective protein (NALCN), Truncated

Uniprot Id

Q8IZF0

Target Species

Human

Target Name

NALCN

Target Full Name

Sodium leak channel NALCN

Target Function

Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Regulates the resting membrane potential and controls neuronal excitability. Neuropeptides such as neurotensin and substance P (SP) stimulate the firing of action potentials by activating NALCN through a SRC family kinases-dependent pathway. In addition to its baseline activity, NALCN activity is enhanced/modulated by several GPCRs. Required for normal respiratory rhythm and neonatal survival. Involved in systemic osmoregulation by controlling the serum sodium concentration. NALCN is partly responsible for the substance P-induced depolarization and regulation of the intestinal pace-making activity in the interstitial cells of Cajal. Plays a critical role in both maintenance of spontaneous firing of substantia nigra pars reticulata (SNr) neurons and physiological modulation of SNr neuron excitability.

Target Involvement

Hypotonia, infantile, with psychomotor retardation and characteristic facies 1 (IHPRF1); Congenital contractures of the limbs and face, hypotonia, and developmental delay (CLIFAHDD)

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Cation-nonselective channel family

Target Synonyms

A530023G15Rik; bA430M15.1; CanIon; Canlon; FLJ23913 ; FLJ44659; FLJ44764; Four repeat voltage gated ion channel; MGC74524; Nalcn; NALCN_HUMAN; Putative 4 repeat voltage gated ion channel; Sodium leak channel non-selective protein; sodium leak channel, non selective; Vgcnl1; VGCNL1 protein; voltage gated channel like 1; Voltage gated channel-like protein 1