Recombinant Human Sodium/nucleoside cotransporter 2 (SLC28A2), Truncated

Uniprot Id

O43868

Target Species

Human

Target Name

SLC28A2

Target Full Name

Sodium/nucleoside cotransporter 2

Target Function

Sodium-dependent and purine-selective transporter. Exhibits the transport characteristics of the nucleoside transport system cif or N1 subtype (N1/cif) (selective for purine nucleosides and uridine). Plays a critical role in specific uptake and salvage of purine nucleosides in kidney and other tissues.

Target Subcellular Location

Membrane; Multi-pass membrane protein.

Target Protein Families

Concentrative nucleoside transporter (CNT) (TC 2.A.41) family

Target Tissue Specificity

Expressed in heart and skeletal muscle followed by liver, kidney, intestine, pancreas, placenta and brain. Weak expression in lung.

Target Synonyms

SLC28A2; CNT2; Sodium/nucleoside cotransporter 2; Concentrative nucleoside transporter 2; CNT 2; hCNT2; Na(+)/nucleoside cotransporter 2; Sodium-coupled nucleoside transporter 2; Sodium/purine nucleoside co-transporter; SPNT; Solute carrier family 28 member 2

Target Background

Enables neurotransmitter transmembrane transporter activity and nucleoside transmembrane transporter activity. Involved in several processes, including nucleoside transport; purine nucleobase transmembrane transport; and pyrimidine-containing compound transmembrane transport. Predicted to be located in membrane. Predicted to be part of brush border membrane; coated vesicle; and vesicle membrane. Predicted to be integral component of plasma membrane.