Recombinant Human Sodium/potassium/calcium exchanger 4 (SLC24A4), Truncated

Uniprot Id

Q8NFF2

Target Species

Human

Target Name

SLC24A4

Target Full Name

Sodium/potassium/calcium exchanger 4

Target Function

Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). Controls the rapid response termination and proper regulation of adaptation in olfactory sensory neurons (OSNs) which subsequently influences how odor information is encoded and perceived. May play a role in calcium transport during amelogenesis.

Target Involvement

Amelogenesis imperfecta, hypomaturation type, 2A5 (AI2A5)

Target Subcellular Location

Cytoplasm. Cell membrane; Multi-pass membrane protein.

Target Protein Families

Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family, SLC24A subfamily

Target Tissue Specificity

Expressed abundantly in all regions of the brain, aorta, lung and thymus. Expressed at lower levels in the stomach and intestine.

Target Synonyms

Na(+)/K(+)/Ca(2+)-exchange protein 4; NCKX4; NCKX4_HUMAN; SHEP6; SLC24A2; SLC24A4; Sodium/potassium/calcium exchanger 4; Solute carrier family 24 (sodium/potassium/calcium exchanger) member 4; Solute carrier family 24 member 4

Target Background

Enables calcium, potassium:sodium antiporter activity. Involved in calcium ion transmembrane transport; potassium ion transmembrane transport; and sodium ion transmembrane transport. Acts upstream of or within cellular calcium ion homeostasis. Part of plasma membrane. Implicated in amelogenesis imperfecta hypomaturation type 2A5.