Recombinant Human Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2), Truncated

Cat.No	ACP05498	Target Name	ATP1A2
Form	Lyophilized powder	Expression System	Custom Production. Please inquire and provide the desire expression system.
Protein Length	Partial	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP05498

Target Name

ATP1A2

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Protein Length

Partial

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	P50993

Background Information

Uniprot Id

P50993
Target Species

Human
Target Name

ATP1A2
Target Full Name

Sodium/potassium-transporting ATPase subunit alpha-2
Target Function

This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients.
Target Involvement

Migraine, familial hemiplegic, 2 (FHM2); Alternating hemiplegia of childhood 1 (AHC1)
Target Subcellular Location

Membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
Target Protein Families

Cation transport ATPase (P-type) (TC 3.A.3) family, Type IIC subfamily
Target Synonyms

AT1A2_HUMAN; Atp1a2; FHM2; KIAA0778; MHP2; Na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ ATPase alpha 2 subunit; Sodium potassium ATPase; Sodium pump subunit alpha 2; Sodium pump subunit alpha-2; Sodium/potassium transporting ATPase alpha 2 chain; Sodium/potassium transporting ATPase subunit alpha 2; Sodium/potassium-transporting ATPase subunit alpha-2
Target Background

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 2 subunit. Mutations in this gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood.

Recombinant Human Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2), Truncated

Specifications

Immunogen Information

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