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Recombinant Human Solute carrier organic anion transporter family member 1B3 (SLCO1B3), Truncated

ACP05702

Number
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High Purity LevelsPrecision and ReliabilityCustomization Options

Specifications


Cat.No ACP05702 Target NameSLCO1B3
FormLyophilized powderExpression SystemCustom Production. Please inquire and provide the desire expression system.
Protein LengthPartialPurity>85% (SDS-PAGE)
Storage Buffer5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information


Target SpeciesHumanUniprot IDQ9NPD5
Background Information
  • Uniprot Id

    Q9NPD5

  • Target Species

    Human

  • Target Name

    SLCO1B3

  • Target Full Name

    Solute carrier organic anion transporter family member 1B3

  • Target Function

    Mediates the Na(+)-independent uptake of organic anions such as 17-beta-glucuronosyl estradiol, taurocholate, triiodothyronine (T3), leukotriene C4, dehydroepiandrosterone sulfate (DHEAS), methotrexate and sulfobromophthalein (BSP). Involved in the clearance of bile acids and organic anions from the liver.

  • Target Involvement

    Hyperbilirubinemia, Rotor type (HBLRR)

  • Target Subcellular Location

    Basolateral cell membrane; Multi-pass membrane protein.

  • Target Protein Families

    Organo anion transporter (TC 2.A.60) family

  • Target Tissue Specificity

    Highly expressed in liver, in particular at the basolateral membrane of hepatocytes near the central vein. Not detected in other tissues. Highly expressed in some cancer cell lines derived from colon, pancreas, liver and gall bladder.

  • Target Synonyms

    HBLRR; Liver-specific organic anion transporter 2; LST-2; LST-3TM13; LST3; OATP-8; OATP1B3; Organic anion transporter 8; Organic anion-transporting polypeptide 8; SLC21A8; SLCO1B3; SO1B3_HUMAN; Solute carrier family 21 member 8; Solute carrier organic anion transporter family member 1B3

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