Recombinant Human Sorting nexin-4 (SNX4)

Uniprot Id

O95219

Target Species

Human

Target Name

SNX4

Target Full Name

Sorting nexin-4

Target Function

Involved in the regulation of endocytosis and in several stages of intracellular trafficking. Plays a role in recycling endocytosed transferrin receptor and prevent its degradation. Involved in autophagosome assembly by regulating trafficking and recycling of phospholipid scramblase ATG9A.

Target Subcellular Location

Early endosome membrane; Peripheral membrane protein; Cytoplasmic side.

Target Protein Families

Sorting nexin family

Target Synonyms

ATG24B; SNX 4; snx4; SNX4_HUMAN; Sorting nexin 4; Sorting nexin-4

Target Background

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members. Two transcript variants, one protein coding and the other non-protein coding, have been found for this gene.