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| Cat.No | ACP13243 | Target Name | NABP1 |
|---|---|---|---|
| Form | Lyophilized powder | Expression System | Custom Production. Please inquire and provide the desire expression system. |
| Expression Range | 1-204 | Protein Length | Full length protein |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96AH0 |
|---|
Uniprot Id
Q96AH0
Target Species
Human
Target Name
NABP1
Target Full Name
SOSS complex subunit B2
Target Function
Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. In the SOSS complex, acts as a sensor of single-stranded DNA that binds to single-stranded DNA, in particular to polypyrimidines. The SOSS complex associates with DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways.
Target Subcellular Location
Nucleus. Note=Localizes to nuclear foci following DNA damage.
Target Protein Families
SOSS-B family, SOSS-B2 subfamily
Target Research Area
Epigenetics and Nuclear Signaling
Target Synonyms
FLJ13624; FLJ22833; hSSB2; MGC111163; Nabp1; Nucleic acid-binding protein 1; OBFC2A; Oligonucleotide/oligosaccharide binding fold containing 2A; Oligonucleotide/oligosaccharide binding fold containing protein 2A; Oligonucleotide/oligosaccharide-binding fold-containing protein 2A; Sensor of single strand DNA complex subunit B2; Sensor of single-strand DNA complex subunit B2; Sensor of ssDNA subunit B2; Single stranded DNA binding protein 2; Single-stranded DNA-binding protein 2; SOSB2_HUMAN; SOSS B2; SOSS complex subunit B2; SOSS-B2; SSB2
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