Recombinant Human Speckle targeted PIP5K1A-regulated poly (A) polymerase (TUT1), Truncated

Uniprot Id

Q9H6E5

Target Species

Human

Target Name

TUT1

Target Full Name

Speckle targeted PIP5K1A-regulated poly(A) polymerase

Target Function

Poly(A) polymerase that creates the 3'-poly(A) tail of specific pre-mRNAs. Localizes to nuclear speckles together with PIP5K1A and mediates polyadenylation of a select set of mRNAs, such as HMOX1. In addition to polyadenylation, it is also required for the 3'-end cleavage of pre-mRNAs: binds to the 3'UTR of targeted pre-mRNAs and promotes the recruitment and assembly of the CPSF complex on the 3'UTR of pre-mRNAs. In addition to adenylyltransferase activity, also has uridylyltransferase activity. However, the ATP ratio is higher than UTP in cells, suggesting that it functions primarily as a poly(A) polymerase. Acts as a specific terminal uridylyltransferase for U6 snRNA in vitro: responsible for a controlled elongation reaction that results in the restoration of the four 3'-terminal UMP-residues found in newly transcribed U6 snRNA. Not involved in replication-dependent histone mRNA degradation.

Target Subcellular Location

Nucleus, nucleolus. Nucleus speckle.

Target Protein Families

DNA polymerase type-B-like family

Target Tissue Specificity

Widely expressed.

Target Synonyms

alpha regulated poly(A) polymerase ; nuclear speckle targeted phosphatidylinositol 4 phosphate 5 kinase type I; nuclear speckle targeted PIPK1A regulated poly(A) polymerase ; PAP associated domain containing 2 ; PAPD2; poly(A) polymerase associated domain containing 2 ; RBM21; RNA binding motif protein 21 ; RNA-binding motif protein 21; RNA-binding protein 21; Speckle targeted PIP5K1A-regulated poly(A) polymerase; Star-PAP; STARPAP; STPAP_HUMAN; terminal uridylyl transferase 1; U6 snRNA specific ; TUT1; TUTase; U6 snRNA specific terminal uridylyltransferase 1; U6 snRNA-specific terminal uridylyltransferase 1; U6 TUTase; U6-TUTase; URLC6