Recombinant Human Spermine oxidase (SMOX)

Cat.No	ACP18901	Target Name	SMOX
Target Synonyms	SMOX; C20orf16; SMO; UNQ3039/PRO9854; Spermine oxidase; EC 1.5.3.16; Polyamine oxidase 1; PAO-1; PAOh1	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Expression Range	1-555
Protein Length	Full length protein	Purity	>85% (SDS-PAGE)
Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Cat.No

ACP18901

Target Name

SMOX

Target Synonyms

SMOX; C20orf16; SMO; UNQ3039/PRO9854; Spermine oxidase; EC 1.5.3.16; Polyamine oxidase 1; PAO-1; PAOh1

Form

Lyophilized powder

Expression System

Custom Production. Please inquire and provide the desire expression system.

Expression Range

1-555

Protein Length

Full length protein

Purity

>85% (SDS-PAGE)

Storage Buffer

5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Target Species	Human	Uniprot ID	Q9NWM0

Background Information

Uniprot Id

Q9NWM0
Target Species

Human
Target Name

SMOX
Target Full Name

Spermine oxidase
Target Function

Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal.
Target Subcellular Location

[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 4]: Cytoplasm. Nucleus.; [Isoform 6]: Cytoplasm. Nucleus.
Target Protein Families

Flavin monoamine oxidase family
Target Tissue Specificity

Widely expressed. Expressed in human tumor cell lines. Isoform 4 is only found in an embryonal kidney cell line.
Target Synonyms

SMOX; C20orf16; SMO; UNQ3039/PRO9854; Spermine oxidase; EC 1.5.3.16; Polyamine oxidase 1; PAO-1; PAOh1
Target Background

Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism.

Recombinant Human Spermine oxidase (SMOX)

Specifications

Immunogen Information

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