Recombinant Human Sphingosine-1-phosphate lyase 1 (SGPL1), Truncated

Uniprot Id

O95470

Target Species

Human

Target Name

SGPL1

Target Full Name

Sphingosine-1-phosphate lyase 1

Target Function

Cleaves phosphorylated sphingoid bases (PSBs), such as sphingosine-1-phosphate, into fatty aldehydes and phosphoethanolamine. Elevates stress-induced ceramide production and apoptosis. Required for global lipid homeostasis in liver and cholesterol homeostasis in fibroblasts. Involved in the regulation of pro-inflammatory response and neutrophil trafficking. Modulates neuronal autophagy via phosphoethanolamine production which regulates accumulation of aggregate-prone proteins such as APP. Seems to play a role in establishing neuronal contact sites and axonal maintenance.

Target Involvement

Nephrotic syndrome 14 (NPHS14)

Target Subcellular Location

Endoplasmic reticulum membrane; Single-pass type III membrane protein; Cytoplasmic side.

Target Protein Families

Group II decarboxylase family, Sphingosine-1-phosphate lyase subfamily

Target Tissue Specificity

Ubiquitously expressed. Expressed in fetal and adult adrenal gland (at protein level).

Target Synonyms

SGPL1; KIAA1252; Sphingosine-1-phosphate lyase 1; S1PL; SP-lyase 1; SPL 1; hSPL; Sphingosine-1-phosphate aldolase

Target Background

Enables sphinganine-1-phosphate aldolase activity. Involved in apoptotic signaling pathway; fatty acid metabolic process; and sphingolipid metabolic process. Located in endoplasmic reticulum. Implicated in nephrotic syndrome type 14.