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| Cat.No | ACP13832 | Target Name | SPSB4 |
|---|---|---|---|
| Target Synonyms | SPSB4; SSB4; SPRY domain-containing SOCS box protein 4; SSB-4 | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Expression Range | 1-273 |
| Protein Length | Full length protein | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | Q96A44 |
|---|
Uniprot Id
Q96A44
Target Species
Human
Target Name
SPSB4
Target Full Name
SPRY domain-containing SOCS box protein 4
Target Function
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5. Diminishes EphB2-dependent cell repulsive responses by mediating the ubiquitination and degradation of EphB2/CTF2. Regulates cellular clock function by mediating the ubiquitin/proteasome-dependent degradation of the circadian transcriptional repressor NR1D1
Target Subcellular Location
Cytoplasm. Cytoplasm, cytosol.
Target Protein Families
SPSB family
Target Synonyms
SPSB4; SSB4; SPRY domain-containing SOCS box protein 4; SSB-4
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