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Recombinant Human SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP), Truncated

ACP11859

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Specifications

Cat.No	ACP11859	Target Name	SLIRP
Target Synonyms	SLIRP; C14orf156; DC23; DC50; PD04872; SRA stem-loop-interacting RNA-binding protein; mitochondrial	Form	Lyophilized powder
Expression System	Custom Production. Please inquire and provide the desire expression system.	Protein Length	Partial
Purity	>85% (SDS-PAGE)	Storage Buffer	5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0.

Immunogen Information

Target Species	Human	Uniprot ID	Q9GZT3

Background Information

Uniprot Id

Q9GZT3
Target Species

Human
Target Name

SLIRP
Target Full Name

SRA stem-loop-interacting RNA-binding protein, mitochondrial
Target Function

RNA-binding protein that acts as a nuclear receptor corepressor. Probably acts by binding the SRA RNA, and repressing the SRA-mediated nuclear receptor coactivation. Binds the STR7 loop of SRA RNA. Also able to repress glucocorticoid (GR), androgen (AR), thyroid (TR) and VDR-mediated transactivation.
Target Subcellular Location

Mitochondrion. Nucleus. Note=Predominantly mitochondrial. Some fraction is nuclear. In the nucleus, it is recruited to nuclear receptor target promoters.
Target Tissue Specificity

Ubiquitously expressed, with highest level in heart, liver, skeletal muscle and testis.
Target Synonyms

SLIRP; C14orf156; DC23; DC50; PD04872; SRA stem-loop-interacting RNA-binding protein; mitochondrial
Target Background

Steroid receptor RNA activator (SRA, or SRA1; MIM 603819) is a complex RNA molecule containing multiple stable stem-loop structures that functions in coactivation of nuclear receptors. SLIRP interacts with stem-loop structure-7 of SRA (STR7) and modulates nuclear receptor transactivation (Hatchell et al., 2006 [PubMed 16762838]).

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Recombinant Human SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP), Truncated

Specifications

Immunogen Information

Inquire Recombinant Human SRA stem-loop-interacting RNA-binding protein, mitochondrial (SLIRP), Truncated Now

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