Recombinant Human Sulfatase-modifying factor 2 (SUMF2)

Uniprot Id

Q8NBJ7

Target Species

Human

Target Name

SUMF2

Target Full Name

Inactive C-alpha-formylglycine-generating enzyme 2

Target Function

Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1.

Target Subcellular Location

Endoplasmic reticulum lumen.

Target Protein Families

Sulfatase-modifying factor family

Target Tissue Specificity

Detected in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in kidney, liver and placenta.

Target Synonyms

SUMF2; PSEC0171; UNQ1968/PRO4500; Inactive C-alpha-formylglycine-generating enzyme 2; Paralog of formylglycine-generating enzyme; pFGE; Sulfatase-modifying factor 2

Target Background

The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.