Recombinant Human Sulfhydryl oxidase 1 (QSOX1), Truncated

Uniprot Id

O00391

Target Species

Human

Target Name

QSOX1

Target Full Name

Sulfhydryl oxidase 1

Target Function

Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. Plays a role in disulfide bond formation in a variety of extracellular proteins. In fibroblasts, required for normal incorporation of laminin into the extracellular matrix, and thereby for normal cell-cell adhesion and cell migration.

Target Subcellular Location

[Isoform 1]: Golgi apparatus membrane; Single-pass membrane protein. Secreted.; [Isoform 2]: Secreted.

Target Protein Families

Quiescin-sulfhydryl oxidase (QSOX) family

Target Tissue Specificity

Expressed in heart, placenta, lung, liver, skeletal muscle, pancreas and very weakly in brain and kidney.

Target Research Area

Cell Biology

Target Synonyms

QSOX1; QSCN6; UNQ2520/PRO6013; Sulfhydryl oxidase 1; hQSOX; Quiescin Q6

Target Background

This gene encodes a protein that contains domains of thioredoxin and ERV1, members of two long-standing gene families. The gene expression is induced as fibroblasts begin to exit the proliferative cycle and enter quiescence, suggesting that this gene plays an important role in growth regulation. Two transcript variants encoding two different isoforms have been found for this gene.