Recombinant Human SUN domain-containing protein 1 (SUN1), Truncated

Uniprot Id

O94901

Target Species

Human

Target Name

SUN1

Target Full Name

SUN domain-containing protein 1

Target Function

As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Required for interkinetic nuclear migration (INM) and essential for nucleokinesis and centrosome-nucleus coupling during radial neuronal migration in the cerebral cortex and during glial migration. Involved in telomere attachment to nuclear envelope in the prophase of meiosis implicating a SUN1/2:KASH5 LINC complex in which SUN1 and SUN2 seem to act at least partial redundantly. Required for gametogenesis and involved in selective gene expression of coding and non-coding RNAs needed for gametogenesis. Helps to define the distribution of nuclear pore complexes (NPCs). Required for efficient localization of SYNE4 in the nuclear envelope. May be involved in nuclear remodeling during sperm head formation in spermatogenenis. May play a role in DNA repair by suppressing non-homologous end joining repair to facilitate the repair of DNA cross-links

Target Subcellular Location

Nucleus inner membrane; Single-pass type II membrane protein.

Target Research Area

Epigenetics and Nuclear Signaling

Target Synonyms

Protein unc-84 homolog A; Sad1 and UNC84 domain containing 1; Sad1/unc 84 protein like 1; Sad1/unc-84 protein-like 1; Sun domain-containing protein 1; Sun1; SUN1_HUMAN; UNC 84 homolog A (C elegans); UNC 84A; UNC84 A; UNC84; UNC84 homolog A (C elegans); UNC84A