Recombinant Human Superoxide dismutase [Cu-Zn] (SOD1)

Uniprot Id

P00441

Target Species

Human

Target Name

SOD1

Target Full Name

Superoxide dismutase [Cu-Zn]

Target Function

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

Target Involvement

Amyotrophic lateral sclerosis 1 (ALS1)

Target Subcellular Location

Cytoplasm. Mitochondrion. Nucleus.

Target Protein Families

Cu-Zn superoxide dismutase family

Target Research Area

Metabolism

Target Synonyms

ALS; ALS1; Amyotrophic lateral sclerosis 1 adult; Cu/Zn SOD; Cu/Zn superoxide dismutase; Epididymis secretory protein Li 44; HEL S 44; Homodimer; hSod1; Indophenoloxidase A; IPOA; Mn superoxide dismutase; SOD; SOD soluble; SOD1; SOD2; SODC; SODC_HUMAN; Superoxide dismutase [Cu-Zn]; Superoxide dismutase 1; Superoxide dismutase 1 soluble; Superoxide dismutase Cu Zn; Superoxide dismutase cystolic

Target Background

The protein encoded by this gene binds copper and zinc ions and is one of two isozymes responsible for destroying free superoxide radicals in the body. The encoded isozyme is a soluble cytoplasmic protein, acting as a homodimer to convert naturally-occuring but harmful superoxide radicals to molecular oxygen and hydrogen peroxide. The other isozyme is a mitochondrial protein. In addition, this protein contains an antimicrobial peptide that displays antibacterial, antifungal, and anti-MRSA activity against E. coli, E. faecalis, S. aureus, S. aureus MRSA LPV+, S. agalactiae, and yeast C. krusei. Mutations in this gene have been implicated as causes of familial amyotrophic lateral sclerosis. Rare transcript variants have been reported for this gene.