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The preparation of this recombinant Human SOCS1 protein was to use gene recombination DNA technology to obtain a recombinant vector connected with a SOCS1 fragment (1-211aa) that could be translated into the SOCS1 protein and then transferred it into E.coli cells to express the recombinant SOCS1 protein molecule. In order to get the target protein with high purity, N-terminal 6xHis tag was used in the production. The purity is 90% determined by SDS-PAGE.SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family.?It is highly conserved among various species, including human, chimpanzee, dog, cow, rat and chicken. SOCS1 was also involved in E3 ubiquitin ligases complex, acting as substrate-recognition modules to mediate the polyubiquitination and subsequent degradation of substrate proteins which may be the key components of cytokine signal transduction pathways. Both two functions of SOC1 are very important to regulate the growth and proliferation of cell. Therefore, numerous studies have speculated that SOCS1 may play a role in regulating tumor growth and proliferation, such as hepatocellular carcinoma, melanoma, gastric cancer, prostate cancer and so on.
The preparation of this recombinant Human SOCS1 protein was to use gene recombination DNA technology to obtain a recombinant vector connected with a SOCS1 fragment (1-211aa) that could be translated into the SOCS1 protein and then transferred it into E.coli cells to express the recombinant SOCS1 protein molecule. In order to get the target protein with high purity, N-terminal 6xHis tag was used in the production. The purity is 90% determined by SDS-PAGE.SOCS1 is a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family.?It is highly conserved among various species, including human, chimpanzee, dog, cow, rat and chicken. SOCS1 was also involved in E3 ubiquitin ligases complex, acting as substrate-recognition modules to mediate the polyubiquitination and subsequent degradation of substrate proteins which may be the key components of cytokine signal transduction pathways. Both two functions of SOC1 are very important to regulate the growth and proliferation of cell. Therefore, numerous studies have speculated that SOCS1 may play a role in regulating tumor growth and proliferation, such as hepatocellular carcinoma, melanoma, gastric cancer, prostate cancer and so on.
| Cat.No | ACP02552 | Target Name | SOCS1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 1-211aa | Mol Weight | 27.6kDa |
| Protein Length | Full length | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O15524 |
|---|
Uniprot Id
O15524
Target Species
Human
Target Name
SOCS1
Target Full Name
Suppressor of cytokine signaling 1
Target Function
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS1 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Through binding to JAKs and IFNGR1, inhibits their kinase activity. In vitro, also suppresses Tec protein-tyrosine activity. Appears to be a major regulator of signaling by interleukin 6 (IL6) and leukemia inhibitory factor (LIF). Regulates interferon-gamma mediated sensory neuron survival. Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Seems to recognize JAK2. SOCS1 appears to be a negative regulator in IGF1R signaling pathway.
Target Subcellular Location
Nucleus. Cytoplasmic vesicle. Note=Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.
Target Protein Families
SOCS1 family
Target Tissue Specificity
Expressed in all tissues with high expression in spleen, small intestine and peripheral blood leukocytes.
Target Research Area
Immunology
Target Synonyms
CISH 1; CISH1; Cytokine inducible SH2 protein 1; JAB; JAK binding protein; JAK-binding protein; Janus kinase binding protein ; SOCS 1; SOCS-1; Socs1; SOCS1_HUMAN; SSI 1; SSI-1; SSI1; STAT induced STAT inhibitor 1; STAT-induced STAT inhibitor 1; Suppressor of cytokine signaling 1; Supressor of cytokine signalling 1; TEC interacting protein 3; Tec-interacting protein 3; TIP 3; TIP-3; TIP3
Target Background
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival.
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