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| Cat.No | ACP21466 | Target Name | SYNM |
|---|---|---|---|
| Target Synonyms | Desmuslin; DMN; KIAA0353; SYN; SYNEM_HUMAN; Synemin alpha ; Synemin; Synemin beta ; Synemin; intermediate filament protein ; SYNM | Form | Lyophilized powder |
| Expression System | Custom Production. Please inquire and provide the desire expression system. | Protein Length | Partial |
| Purity | >85% (SDS-PAGE) | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | O15061 |
|---|
Uniprot Id
O15061
Target Species
Human
Target Name
SYNM
Target Full Name
Synemin
Target Function
Type-VI intermediate filament (IF) which plays an important cytoskeletal role within the muscle cell cytoskeleton. It forms heteromeric IFs with desmin and/or vimentin, and via its interaction with cytoskeletal proteins alpha-dystrobrevin, dystrophin, talin-1, utrophin and vinculin, is able to link these heteromeric IFs to adherens-type junctions, such as to the costameres, neuromuscular junctions, and myotendinous junctions within striated muscle cells.
Target Subcellular Location
Cytoplasm, cytoskeleton. Cell junction, adherens junction. Note=There are at least two distinct SYNM subpopulations, one in which SYMN interacts with DES within the Z-lines, and another in which it interacts with both DTNA and DES at the costamere.
Target Protein Families
Intermediate filament family
Target Tissue Specificity
Isoform 2 is strongly detected in adult heart, fetal skeletal muscles and fetal heart. Isoform 1 is weakly detected in fetal heart and also in fetal skeletal muscle. Isoform 1 and isoform 2 are detected in adult bladder (at protein level). The mRNA is pre
Target Synonyms
Desmuslin; DMN; KIAA0353; SYN; SYNEM_HUMAN; Synemin alpha ; Synemin; Synemin beta ; Synemin; intermediate filament protein ; SYNM
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