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To express the recombinant Human STXBP1 protein in mammalian cells, a DNA fragment encoding the Human STXBP1 protein (1-594aa) is inserted into a plasmid vector and transferred to the mammalian cells. Cells containing the plasmid are screened, cultured, and induced to express the STXBP1 protein. The protein carries a N-terminal 6xHis tag. Lysing the cells allows for the collection of the recombinant Human STXBP1 protein, which is purified through affinity purification and then identified through SDS-PAGE and subsequent staining of the gel with Coomassie Brilliant Blue. The purity of the recombinant Human STXBP1 protein obtained is greater than 85%.
To express the recombinant Human STXBP1 protein in mammalian cells, a DNA fragment encoding the Human STXBP1 protein (1-594aa) is inserted into a plasmid vector and transferred to the mammalian cells. Cells containing the plasmid are screened, cultured, and induced to express the STXBP1 protein. The protein carries a N-terminal 6xHis tag. Lysing the cells allows for the collection of the recombinant Human STXBP1 protein, which is purified through affinity purification and then identified through SDS-PAGE and subsequent staining of the gel with Coomassie Brilliant Blue. The purity of the recombinant Human STXBP1 protein obtained is greater than 85%.
| Cat.No | ACP05094 | Target Name | STXBP1 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | Mammalian cell |
| Expression Range | 1-594aa | Mol Weight | 68.6 |
| Protein Length | Full length | Purity | >85% (SDS-PAGE) |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P61764 |
|---|
Uniprot Id
P61764
Target Species
Human
Target Name
STXBP1
Target Full Name
Syntaxin-binding protein 1
Target Function
Participates in the regulation of synaptic vesicle docking and fusion through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions.
Target Involvement
Epileptic encephalopathy, early infantile, 4 (EIEE4)
Target Subcellular Location
Cytoplasm, cytosol. Membrane; Peripheral membrane protein.
Target Protein Families
STXBP/unc-18/SEC1 family
Target Tissue Specificity
Brain and spinal cord. Highly enriched in axons.
Target Research Area
Cancer, Transport
Target Synonyms
FLJ37475; Munc 18 1; Munc 18a; MUNC18 1; N-Sec1; Neuronal SEC1; NSec1; p67; Protein unc-18 homolog 1; Protein unc-18 homolog A; Rb sec1; RBSEC1; STXB1_HUMAN; STXBP1; Syntaxin binding protein 1; Syntaxin-binding protein 1; Unc 18 homolog; Unc 18A; Unc-18A; Unc18 1; UNC18; Unc18-1
Target Background
This gene encodes a syntaxin-binding protein. The encoded protein appears to play a role in release of neurotransmitters via regulation of syntaxin, a transmembrane attachment protein receptor. Mutations in this gene have been associated with infantile epileptic encephalopathy-4. Alternatively spliced transcript variants have been described.
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