Recombinant Human T-box transcription factor TBX4 (TBX4)

Uniprot Id

P57082

Target Species

Human

Target Name

TBX4

Target Full Name

T-box transcription factor TBX4

Target Function

Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs.

Target Involvement

Ischiocoxopodopatellar syndrome (ICPPS)

Target Subcellular Location

Nucleus.

Target Synonyms

SPS; T box 4 ; T box protein 4; T box transcription factor TBX 4; T box transcription factor TBX4; T-box protein 4; T-box transcription factor TBX4; TBX 4; TBX4; TBX4_HUMAN

Target Background

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity.