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The production of this Recombinant Human TRBC2 protein started with the TRBC2 gene synthesis. And then using recombinant DNA technology, the TRBC2 gene was inserted into an expression vector so that we could get the recombinant express plasmid of TRBC2. Transform the plasmid into the cells of E.coli, culture the cells and we could get the desired Recombinant Human TRBC2 protein. But the work was not completed, protein purification and a strict QC system were performed in the last step. The purity is 85%+ determined by SDS-PAGE.TRBC2 (also named TCRBC2) is a gene providing an instruction of making a protein named T cell receptor beta constant 2 (TRBC2) in human. TRBC2 protein can bind to antigen and immunoglobulin receptor and is involved multiple biological processes. These processes include B cell receptor signaling pathway, complement activation, classical pathway, defense response to bacterium, innate immune response, positive regulation of B cell activation, etc.
The production of this Recombinant Human TRBC2 protein started with the TRBC2 gene synthesis. And then using recombinant DNA technology, the TRBC2 gene was inserted into an expression vector so that we could get the recombinant express plasmid of TRBC2. Transform the plasmid into the cells of E.coli, culture the cells and we could get the desired Recombinant Human TRBC2 protein. But the work was not completed, protein purification and a strict QC system were performed in the last step. The purity is 85%+ determined by SDS-PAGE.TRBC2 (also named TCRBC2) is a gene providing an instruction of making a protein named T cell receptor beta constant 2 (TRBC2) in human. TRBC2 protein can bind to antigen and immunoglobulin receptor and is involved multiple biological processes. These processes include B cell receptor signaling pathway, complement activation, classical pathway, defense response to bacterium, innate immune response, positive regulation of B cell activation, etc.
| Cat.No | ACP08680 | Target Name | TRBC2 |
|---|---|---|---|
| Target Synonyms | TRBC2; TCRBC2; T cell receptor beta constant 2 | Form | Liquid or Lyophilized powder |
| Expression System | E.coli | Expression Range | 1-129aa |
| Mol Weight | 19.7 kDa | Protein Length | Partial |
| Purity | Greater than 85% as determined by SDS-PAGE. | Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | A0A5B9 |
|---|
Uniprot Id
A0A5B9
Target Species
Human
Target Name
TRBC2
Target Full Name
T cell receptor beta constant 2
Target Function
Constant region of T cell receptor (TR) beta chain. Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens. Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation. The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity.
Target Subcellular Location
Cell membrane.
Target Research Area
Others
Target Synonyms
TRBC2; TCRBC2; T cell receptor beta constant 2
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