Chinese (Simplified)
English
German
Korean
Spanish
Sign up for an account to enjoy easy online shopping and instant order tracking.
Amino acids 2-535 form the expressed segment for recombinant Human CCT2. The expected molecular weight for the CCT2 protein is calculated to be 73.4 kDa. The CCT2 protein was expressed in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of CCT2, making it easier to detect and purify the CCT2 recombinant protein in the later stages of expression and purification.T-complex protein 1 subunit beta (CCT2) is a crucial molecular chaperone in cells, primarily involved in the process of protein folding. Research on CCT2 plays a vital role in our understanding of protein folding and maintaining structural integrity within cells. In cancer research, the expression of CCT2 is associated with various types of tumors, particularly playing a significant role in the proliferation and invasion of tumor cells. Scientists aim to uncover the molecular mechanisms of CCT2 in cancer development, hoping to provide new targets for cancer treatment. Additionally, CCT2 is linked to research on neurological disorders. Its function in neurons may be related to the occurrence of neurodegenerative diseases. Scientists are working to gain a deeper understanding of the role of CCT2 in the nervous system, aiming to provide new clues for the treatment of related diseases.
Amino acids 2-535 form the expressed segment for recombinant Human CCT2. The expected molecular weight for the CCT2 protein is calculated to be 73.4 kDa. The CCT2 protein was expressed in e.coli. The N-terminal 6xHis-SUMO tag was fused into the coding gene segment of CCT2, making it easier to detect and purify the CCT2 recombinant protein in the later stages of expression and purification.T-complex protein 1 subunit beta (CCT2) is a crucial molecular chaperone in cells, primarily involved in the process of protein folding. Research on CCT2 plays a vital role in our understanding of protein folding and maintaining structural integrity within cells. In cancer research, the expression of CCT2 is associated with various types of tumors, particularly playing a significant role in the proliferation and invasion of tumor cells. Scientists aim to uncover the molecular mechanisms of CCT2 in cancer development, hoping to provide new targets for cancer treatment. Additionally, CCT2 is linked to research on neurological disorders. Its function in neurons may be related to the occurrence of neurodegenerative diseases. Scientists are working to gain a deeper understanding of the role of CCT2 in the nervous system, aiming to provide new clues for the treatment of related diseases.
| Cat.No | ACP02437 | Target Name | CCT2 |
|---|---|---|---|
| Form | Liquid or Lyophilized powder | Expression System | E.coli |
| Expression Range | 2-535aa | Mol Weight | 70.3 kDa |
| Protein Length | Full Length of Mature Protein | Purity | Greater than 90% as determined by SDS-PAGE. |
| Storage Buffer | 5%-50% glycerol. Lyophilized powder form: the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, Liquid form: default storage buffer is Tris/PBS-based buffer, pH 8.0. |
| Target Species | Human | Uniprot ID | P78371 |
|---|
Uniprot Id
P78371
Target Species
Human
Target Name
CCT2
Target Full Name
T-complex protein 1 subunit beta
Target Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.
Target Subcellular Location
Cytoplasm.
Target Protein Families
TCP-1 chaperonin family
Target Research Area
Signal Transduction
Target Synonyms
99D8.1; CCT 2; CCT beta; CCT-beta; CCT2; CCTB; Chaperonin containing t complex polypeptide 1 beta subunit; Chaperonin containing t complex polypeptide 1 subunit 2; Chaperonin containing TCP1 subunit 2; Chaperonin containing TCP1 subunit 2 (beta); CTP:phosphocholine cytidylyltransferase 2; Epididymis secretory sperm binding protein Li 100n; HEL S 100n; MGC142074; MGC142076; MGC94480; PRO1633; T complex protein 1 beta subunit; T complex protein 1 subunit beta; T-complex protein 1 subunit beta; TCP 1 beta; TCP-1-beta; TCPB_HUMAN
Target Background
The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Two transcript variants encoding different isoforms have been found for this gene.
Free shipping on orders $999+
Advenit post multos Scudilo Scutariorum tribunus velament
We accept credit cards, PayPal, and bank wires
Responsive and knowledgable customer service via email, text or phone
Notification
