Recombinant Human T-complex protein 1 subunit theta (CCT8)

Uniprot Id

P50990

Target Species

Human

Target Name

CCT8

Target Full Name

T-complex protein 1 subunit theta

Target Function

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.

Target Subcellular Location

Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body.

Target Protein Families

TCP-1 chaperonin family

Target Synonyms

CCT8; C21orf112; CCTQ; KIAA0002; T-complex protein 1 subunit theta; TCP-1-theta; CCT-theta; Chaperonin containing T-complex polypeptide 1 subunit 8; Renal carcinoma antigen NY-REN-15

Target Background

This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1.