Recombinant Human Tau-tubulin kinase 2 (TTBK2), Truncated

Uniprot Id

Q6IQ55

Target Species

Human

Target Name

TTBK2

Target Full Name

Tau-tubulin kinase 2

Target Function

Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.

Target Involvement

Spinocerebellar ataxia 11 (SCA11)

Target Subcellular Location

Cell projection, cilium. Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Cytoplasm, cytosol. Nucleus.

Target Protein Families

Protein kinase superfamily, CK1 Ser/Thr protein kinase family

Target Research Area

Neuroscience

Target Synonyms

TTBK2; KIAA0847; Tau-tubulin kinase 2; EC 2.7.11.1

Target Background

This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem.